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The localization of the functional glucocorticoid receptor alpha in human bone.

Abstract:

Glucocorticoids have well-documented effects on the skeleton, although their mechanism of action is still poorly understood. The actions of glucocorticoids on bone cells are mediated, in part, directly via specific receptors. The presence of these receptors has been demonstrated in both rodent and human osteoblastic cells in vitro, but their presence in human bone in vivo has not been reported. In this study, we have used specific affinity purified polyclonal antibodies to the functional gluc...

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Publication status:
Published

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Publisher copy:
10.1210/jc.85.2.883

Authors


Triffitt, JT More by this author
Compston, JE More by this author
Journal:
The Journal of clinical endocrinology and metabolism
Volume:
85
Issue:
2
Pages:
883-889
Publication date:
2000-02-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:96724f97-9a94-456d-8917-c01c29e5549c
Source identifiers:
108571
Local pid:
pubs:108571

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