Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains.

Journal article

A viral aetiology has long been suspected for Alzheimer's disease (AD) but until now, techniques have not been sufficiently sensitive to provide clear evidence for or against the presence of any viral genome in AD brain. We have used the very highly sensitive method of polymerase chain reaction to look for herpes simplex virus type 1 (HSV1) DNA, specifically the viral thymidine kinase (TK) gene, in autopsy brain specimens. DNA-samples from HSV-infected and uninfected Vero cells have been exam...

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Authors: Jamieson, G; Maitland, N; Wilcock, G; Craske, J; Itzhaki, R

• Publication status: Published
• Journal: Journal of medical virology
• Volume: 33
• Issue: 4
• Pages: 224-227
• Publication date: 1991-04-01
• DOI: 10.1002/jmv.1890330403
• EISSN: 1096-9071
• ISSN: 0146-6615
• Language: English
• Keywords: Herpes Simplex; Thymidine Kinase; Simplexvirus; Humans; Alzheimer Disease; Disease Susceptibility; Vero Cells; Sensitivity and Specificity; DNA, Viral; Genes, Viral; Cercopithecus aethiops; Hypoxanthine Phosphoribosyltransferase; Animals; Polymerase Chain Reaction