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Myeloid-derived suppressor cells expand during breast cancer progression and promote tumor-induced bone destruction.

Abstract:

Myeloid-derived suppressor cells (MDSCs), identified as Gr1(+)CD11b(+) cells in mice, expand during cancer and promote tumor growth, recurrence and burden. However, little is known about their role in bone metastases. We hypothesized that MDSCs may contribute to tumor-induced bone disease, and inoculated breast cancer cells into the left cardiac ventricle of nude mice. Disease progression was monitored weekly by X-ray and fluorescence imaging and MDSCs expansion by fluorescence-activated cell...

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Publication status:
Published

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Publisher copy:
10.4161/onci.21990

Authors


Danilin, S More by this author
Merkel, AR More by this author
Johnson, JR More by this author
Johnson, RW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Oncoimmunology
Volume:
1
Issue:
9
Pages:
1484-1494
Publication date:
2012-12-05
DOI:
EISSN:
2162-402X
ISSN:
2162-4011
URN:
uuid:9668badd-710a-48aa-ad0a-0dce8425e5d9
Source identifiers:
369881
Local pid:
pubs:369881

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