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Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.

Abstract:

Synthesis of deoxynucleoside triphosphates (dNTPs) is required for both DNA replication and DNA repair and is catalyzed by ribonucleotide reductases (RNR), which convert ribonucleotides to their deoxy forms [1, 2]. Maintaining the correct levels of dNTPs for DNA synthesis is important for minimizing the mutation rate [3-7], and this is achieved by tight regulation of RNR [2, 8, 9]. In fission yeast, RNR is regulated in part by a small protein inhibitor, Spd1, which is degraded in S phase and ...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2012.02.070

Authors


Salguero, I More by this author
Guarino, E More by this author
Shepherd, ME More by this author
Deegan, TD More by this author
Havens, CG More by this author
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Journal:
Current biology : CB
Volume:
22
Issue:
8
Pages:
720-726
Publication date:
2012-04-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:965e3180-3c85-47a5-91dd-2a65c098beb4
Source identifiers:
322945
Local pid:
pubs:322945

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