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Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.

Abstract:

The NH(2)- and COOH-termini of the ATP-sensitive potassium (K(ATP)) channel pore-forming subunit, Kir6.2, both lie intracellularly and interact with one another. To study this interaction, cyan fluorescent protein (CFP) and yellow fluorescent protein (YFP) were fused to the NH(2)- and COOH-termini of Kir6.2, respectively (CFP-Kir6.2-YFP). These fluorescent proteins have sufficient spectral overlap to allow distance-dependent fluorescence resonance energy transfer (FRET). When CFP-Kir6.2-YFP w...

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Publication status:
Published

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Authors


Lippiat, JD More by this author
Albinson, SL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Diabetes
Volume:
51 Suppl 3
Issue:
SUPPL. 3
Pages:
S377-S380
Publication date:
2002-12-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:96591868-d601-4fc1-ace3-202f797c06f9
Source identifiers:
114314
Local pid:
pubs:114314

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