Advances in understanding chromosome silencing by the long non-coding RNA Xist.

Journal article

In female mammals, one of the two X chromosomes becomes genetically silenced to compensate for dosage imbalance of X-linked genes between XX females and XY males. X chromosome inactivation (X-inactivation) is a classical model for epigenetic gene regulation in mammals and has been studied for half a century. In the last two decades, efforts have been focused on the X inactive-specific transcript (Xist) locus, discovered to be the master regulator of X-inactivation. The Xist gene produces a no...

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Authors: Sado, T; Brockdorff, N

• Publication status: Published
• Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• Volume: 368
• Issue: 1609
• Pages: 20110325
• Publication date: 2013-01-01
• DOI: 10.1098/rstb.2011.0325
• EISSN: 1471-2970
• ISSN: 0962-8436
• Language: English
• Keywords: X Chromosome Inactivation; Cell Differentiation; Genes, X-Linked; Genetic Loci; Animals; Cell Cycle Proteins; Chromosomes, Human, X; RNA, Long Noncoding; Alleles; Female; Male; Transcription, Genetic; Embryonic Stem Cells; Humans; Histones