- Abstract:
- Concepts: The formation of stereochemically defined bis-THF units through a double cyclization and a hydride-shift-initiated route to spiroketals is described (see scheme; Xc=chiral auxiliary). The resulting sequence has been used in a synthesis of the C1-16 fragment of the naturally occurring antitumor agent pectenotoxin-4.
- Publication status:
- Published
- Journal:
- Angewandte Chemie (International ed. in English)
- Volume:
- 52
- Issue:
- 9
- Pages:
- 2491-2494
- Publication date:
- 2013-02-05
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- URN:
-
uuid:9653d773-4256-40f4-8023-4ae3eb24e668
- Source identifiers:
-
375685
- Local pid:
- pubs:375685
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
Interplay of cascade oxidative cyclization and hydride shifts in the synthesis of the ABC spiroketal ring system of pectenotoxin-4.
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