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Disease model distortion in association studies

Abstract:

Most findings from genome-wide association studies (GWAS) are consistent with a simple disease model at a singel nucleotide polymorphism, in which each additional copy of the risk allele increases risk by the same multiplicative factor, in contrast to dominance or interaction effects. As others have noted, departures from this multiplicative model are difficult to detect. Here, we seek to quantify this both analytically and empirically. We show that imperfect linkage disequilibrium (LD) betwe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/gepi.20576

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
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Funding agency for:
Eliana Hechter
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Funding agency for:
Peter Donnelly
Wellcome Trust More from this funder
Publisher:
Wiley Publisher's website
Journal:
Genetic Epidemiology Journal website
Volume:
35
Issue:
4
Pages:
278-290
Publication date:
2011-05-05
DOI:
EISSN:
1098-2272
URN:
uuid:9653401a-bbef-4310-8752-7860f2746494
Local pid:
ora:5387

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