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Impact of micropolymorphism outside the 1 peptide binding groove in the clinically-relevant allele HLA-C*14 on T cell responses in HIV-1 infection

Abstract:

There is increasing evidence for the importance of HLA-C-restricted CD8+ 28 T-cells in HIV-1 control, but these responses are relatively poorly investigated. Numbers of HLA-C-restricted HIV-1 epitopes identified are much smaller than those of HLA-A-restricted or HLA-B-restricted ones. Here, we utilized a mass spectrometry-based approach to identify HIV-1 peptides presented by HLA-C*14:03 protective and HLA-C*14:02 non-protective alleles. We identified twenty-five 8-11mer HLA-I-bound HIV-1 pep...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1128/jvi.00432-22

Authors


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Name:
Medical Research Council
Grant:
MR/K012037/1
Publisher:
American Society for Microbiology
Journal:
Journal of Virology More from this journal
Volume:
96
Issue:
10
Article number:
e00432-22
Publication date:
2022-04-27
Acceptance date:
2022-04-10
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
1249884
Local pid:
pubs:1249884
Deposit date:
2022-04-10

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