Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens.

Journal article

Blood-feeding ectoparasites, such as mosquitoes, sandflies and ticks, transmit many disease agents. Their control relies on large-scale, repeated use of chemical pesticides. An alternative, targeted and environmentally friendly approach is to develop anti-ectoparasite vaccines. We describe a vaccine to control ticks that targets an 'exposed' tick saliva antigen and cross-reacts with 'concealed' tick midgut antigens. Ticks feeding on immunised animals induced a cutaneous inflammatory response ...

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Authors: Trimnell, A; Hails, R; Nuttall, P

• Publication status: Published
• Journal: Vaccine
• Volume: 20
• Issue: 29-30
• Pages: 3560-3568
• Publication date: 2002-10-01
• DOI: 10.1016/s0264-410x(02)00334-1
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Antigens; Cross Reactions; Guinea Pigs; Tick Infestations; Molecular Sequence Data; Animals; Immunization; Ticks; Insect Proteins; Amino Acid Sequence; Vaccines