Acoustic Cavitation Enhances Focused Ultrasound Ablation with Phase-Shift Inorganic Perfluorohexane Nanoemulsions: An In Vitro Study Using a Clinical Device

Journal article

Purpose. To investigate whether acoustic cavitation could increase the evaporation of a phase-shift inorganic perfluorohexane (PFH) nanoemulsion and enhance high intensity focused ultrasound (HIFU) ablation. Materials and Methods. PFH was encapsulated by mesoporous silica nanocapsule (MSNC) to form a nanometer-sized droplet (MSNC-PFH). It was added to a tissue-mimicking phantom, whereas phosphate buffered saline (PBS) was added as a control (PBS-control). HIFU (P ac = 150 W, t = 5/10 s) expos...

Expand abstract

Authors: Zhao, L; Zou, J; Chen, Z; Liu, S; Jiao, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Hindawi Publishing Corporation
• Journal: BioMed Research International
• Volume: 2016
• Pages: Article ID 7936902
• Publication date: 2016-05-15
• Acceptance date: 2016-05-15
• DOI: 10.1155/2016/7936902
• EISSN: 2314-6141
• ISSN: 2314-6133
• Pmid: 27419138
• Language: English
• Keywords: High-Energy Shock Waves; High-Intensity Focused Ultrasound Ablation; Inorganic Chemicals; Nanocapsules; Equipment Design; In Vitro Techniques; Materials Testing; Journal Article; Fluorocarbons; Treatment Outcome; Equipment Failure Analysis; Gases; research-article; Particle Size