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DNA-immunisation with dengue virus E protein domains I/II, but not domain III, enhances Zika, West Nile and Yellow Fever virus infection

Abstract:

Dengue virus (DENV), the causative agent of dengue disease, is among the most important mosquito-borne pathogens worldwide. DENV is composed of four closely related serotypes and belongs to the Flaviviridae family alongside other important arthropod-borne viral pathogens such as Zika virus (ZIKV), West Nile virus (WNV) and Yellow Fever virus (YFV). After infection, the antibody response is mostly directed to the viral E glycoprotein which is composed of three structural domains named DI, DII ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pone.0181734

Authors


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Institution:
University of Oxford
Division:
Medical Sciences
Department:
Nuffield Department of Medicine; Human Genetics Wt Centre
ORCID:
0000-0002-0012-5247
Poggianella, M More by this author
Marchese, S More by this author
Mossenta, M More by this author
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
12
Issue:
7
Pages:
19
Publication date:
2017-07-25
Acceptance date:
2017-07-06
DOI:
EISSN:
1932-6203
Pubs id:
pubs:863433
URN:
uri:96469cea-846d-4c54-a757-ff7429eb952b
UUID:
uuid:96469cea-846d-4c54-a757-ff7429eb952b
Local pid:
pubs:863433

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