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Development of ceftazidime resistance in an acute Burkholderia pseudomallei infection.

Abstract:

Burkholderia pseudomallei, a bacterium that causes the disease melioidosis, is intrinsically resistant to many antibiotics. First-line antibiotic therapy for treating melioidosis is usually the synthetic β-lactam, ceftazidime (CAZ), as almost all B. pseudomallei strains are susceptible to this drug. However, acquired CAZ resistance can develop in vivo during treatment with CAZ, which can lead to mortality if therapy is not switched to a different drug in a timely manner. Serial B. pseudomalle...

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Publisher copy:
10.2147/idr.s35529

Authors


Sarovich, DS More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Von Schulze, AT More by this author
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Journal:
Infection and drug resistance
Volume:
5
Issue:
1
Pages:
129-132
Publication date:
2012
DOI:
EISSN:
1178-6973
ISSN:
1178-6973
URN:
uuid:96466102-9864-4525-9c87-85f72de05195
Source identifiers:
352479
Local pid:
pubs:352479

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