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The CD46-Jagged1 interaction is critical for human TH1 immunity.

Abstract:

CD46 is a complement regulator with important roles related to the immune response. CD46 functions as a pathogen receptor and is a potent costimulator for the induction of interferon-γ (IFN-γ)-secreting effector T helper type 1 (T(H)1) cells and their subsequent switch into interleukin 10 (IL-10)-producing regulatory T cells. Here we identified the Notch family member Jagged1 as a physiological ligand for CD46. Furthermore, we found that CD46 regulated the expression of Notch receptors and li...

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Publication status:
Published

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Publisher copy:
10.1038/ni.2454

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Journal:
Nature immunology
Volume:
13
Issue:
12
Pages:
1213-1221
Publication date:
2012-12-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:9642991e-c966-4cec-bb10-14a72db93ca8
Source identifiers:
356651
Local pid:
pubs:356651

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