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Nicotine amplifies reward-related dopamine signals in striatum.

Abstract:

Reward-seeking behaviors depend critically on dopamine signaling--dopamine neurons encode reward-related information by switching from tonic to phasic (burst-like) activity. Using guinea pig brain slices, we show that nicotine, like cocaine and amphetamine, acts directly in striatum where it enhances dopamine release during phasic but not tonic activity. This amplification provides a mechanism for nicotine facilitation of reward-related dopamine signals, including responses to other primary r...

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Publication status:
Published

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Publisher copy:
10.1038/nn1244

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Nature neuroscience
Volume:
7
Issue:
6
Pages:
583-584
Publication date:
2004-06-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:963ef4ce-9d6d-4663-b924-6161fc75d610
Source identifiers:
114171
Local pid:
pubs:114171

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