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Modelling Spatially Regulated beta−Catenin Dynamics and Invasion in Intestinal Crypts

Abstract:
Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mouse and rat to human) and throughout the different regions of the small and large intestines. In this article, we construct a partial differential equation model of a single colonic crypt that

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Publisher copy:
10.1016/j.bpj.2010.05.016

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Journal:
Biophysical Journal
Volume:
99
Issue:
3
Pages:
716-725
Publication date:
2010-01-01
DOI:
URN:
uuid:9637e0c4-7c6d-49b4-a919-ef7be18986a7
Local pid:
cs:5035

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