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RGDS-fuctionalized alginates improve the survival rate of encapsulated embryonic stem cells during cryopreservation.

Abstract:

Cryopreservation of stem cells, especially embryonic stem cells, is problematic because of low post-thaw cell survival rates and spontaneous differentiation following recovery. In this investigation, mouse embryonic stem cells (mESCs) were encapsulated in arginine-glycine-aspartic acid-serine (RGDS)-coupled calcium alginates (1.2 percent, w/v), allowed to attach to the substratum and then cryopreserved in 10 percent (v/v) dimethyl sulfoxide (DMSO) solution at a slow cooling rate of 1 C per mi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Role:
Author
Journal:
Cryo letters
Volume:
32
Issue:
5
Pages:
389-401
Publication date:
2011-01-01
ISSN:
0143-2044
URN:
uuid:962cdb4a-11ab-4147-a814-d943b5d82179
Source identifiers:
193188
Local pid:
pubs:193188

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