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Calcium mobilisation and CCK secretion induced by modified fatty acids and latex microspheres reveal dual receptor mechanisms for lipid stimulation of STC-1 cells.

Abstract:

How fatty acids stimulate enteroendocrine cells to release cholecystokinin (CCK) is largely unknown. Recently, we proposed that the murine enteroendocrine cell line, STC-1, responds to insoluble fatty acid aggregates rather than fatty acid monomers in solution. This hypothesis led to two testable predictions. First, other insoluble particles of similar size but unrelated to fatty acid may be able to stimulate STC-1 cells in a similar fashion to dodecanoic acid and second, fatty acid sensing i...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
The Journal of physiology
Volume:
553
Issue:
Pt 3
Pages:
759-773
Publication date:
2003-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:9628b9b3-f040-4b68-99f2-2fb288b9b690
Source identifiers:
52120
Local pid:
pubs:52120

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