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Journal article

Human bone marrow stromal cells protect prostate cancer cells from TRAIL-induced apoptosis.

Abstract:

UNLABELLED: Tumor-derived OPG has recently been shown to protect prostate cancer cells from apoptosis. This study has confirmed that bone marrow stromal cell-derived OPG also suppresses cytokine-induced apoptosis in this tumor type, suggesting that it may be the presence of bone-derived OPG that is responsible for the observed preference of these cells in colonizing the skeleton. INTRODUCTION: Metastasis to the skeleton occurs in around 70% of patients with advanced prostate cancer (CaP), su...

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Publication status:
Published

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Publisher copy:
10.1359/jbmr.040703

Authors


Lippitt, J More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
19
Issue:
10
Pages:
1712-1721
Publication date:
2004-10-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:960d11fc-7d4f-4c7a-a837-478cd397411b
Source identifiers:
120717
Local pid:
pubs:120717

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