High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells.

Journal article

Cholesterol- and glycosphingolipid-enriched membrane lipid microdomains, frequently called lipid rafts, are thought to play an important role in the spatial and temporal organization of immunological synapses. Higher ordering of lipid acyl chains was suggested for these entities and imaging of membrane order in living cells during activation can therefore help to understand the mechanisms responsible for the supramolecular organization of molecules involved in the activation of T cells. Here,...

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Authors: Owen, D; Oddos, S; Kumar, S; Davis, D; Neil, M

• Journal: Molecular membrane biology
• Volume: 27
• Issue: 4-6
• Pages: 178-189
• Publication date: 2010-08-01
• DOI: 10.3109/09687688.2010.495353
• EISSN: 1464-5203
• ISSN: 0968-7688
• Language: English
• Keywords: Antigen-Presenting Cells; Humans; T-Lymphocytes; Jurkat Cells; Microscopy, Fluorescence; Phosphatidylcholines; Ketocholesterols; Membrane Microdomains; Animals; 1,2-Dipalmitoylphosphatidylcholine; Immunological Synapses; Membrane Lipids