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Journal article

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.

Abstract:

Low-grade noninvasive papillary bladder tumors are genetically stable whereas muscle invasive bladder tumors display high levels of chromosomal aberrations. As cells deficient for nonhomologous end-joining (NHEJ) pathway components display increased genomic instability, we sought to determine the NHEJ repair characteristics of bladder tumors and correlate this with tumor stage and grade. A panel of 13 human bladder tumors of defined stage and grade were investigated for chromosomal aberration...

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Publication status:
Published

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Publisher copy:
10.1002/gcc.20641

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Journal:
Genes, chromosomes and cancer
Volume:
48
Issue:
4
Pages:
310-321
Publication date:
2009-04-05
DOI:
EISSN:
1098-2264
ISSN:
1045-2257
URN:
uuid:95ec75b2-62a4-4c65-b308-07ba3af1066a
Source identifiers:
131026
Local pid:
pubs:131026

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