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Discovering genetic variation in populations using next generation sequencing and de novo assembly

Alternative title:
Linked de Bruijn Graphs for genome assembly and variant calling
Abstract:

The de Bruijn Graph is a simple and efficient data structure that is used in many areas of sequence analysis including genome assembly, sequencing error correction, sequencing read compression and variant discovery. The data structure has a single parameter k, is straightforward to implement and is tractable for large genomes with high sequencing depth. It also enables representation of multiple samples simultaneously to facilitate comparison. However, unlike the string graph, a de Bruijn ...

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Division:
MPLS
Department:
Statistics
Department:
Department of Statistics
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Examiner
Department:
University of Iceland
Role:
Examiner
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:95c721f4-4bf5-48ef-8b16-0ca28e592bc5
Deposit date:
2019-05-04

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