Heterogeneity within colorectal cancer cell lines and epigenetic regulation of CD24

Thesis

Abstract:: Understanding the mechanisms and nature of tumour heterogeneity is a key focus of current cancer research. Tumour heterogeneity can arise from clonal evolution and/or differentiation. This thesis investigated the role of methylation in dynamic regulation of CD24 based heterogeneity in colorectal cancer cell lines. First, E-Cadherin variation between the cell lines LS174T and LS180 was investigated to find out whether E-Cadherin had any causal role in the difference in lumen formation betwe...
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Files:: Ibn_Ayub_2016_Heterogeneity_within_colorectal.pdf

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Division:: MSD
Department:: Oncology
Department:: Department of Genetic Engineering and Biotechnology, University of Dhaka
Role:: Author

Language:: English
Keywords:: Tumour heterogeneity

Colorectal cancer

Epigenetic regulation

CD24

Dynamic control
Subjects:: Molecular Oncology
UUID:: uuid:95c20af5-8167-4f9f-a136-6c48a366bbad
Deposit date:: 2018-04-24

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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