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Thesis

Heterogeneity within colorectal cancer cell lines and epigenetic regulation of CD24

Abstract:

Understanding the mechanisms and nature of tumour heterogeneity is a key focus of current cancer research. Tumour heterogeneity can arise from clonal evolution and/or differentiation. This thesis investigated the role of methylation in dynamic regulation of CD24 based heterogeneity in colorectal cancer cell lines. First, E-Cadherin variation between the cell lines LS174T and LS180 was investigated to find out whether E-Cadherin had any causal role in the difference in lumen formation betwe...

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Department:
Department of Genetic Engineering and Biotechnology, University of Dhaka

Contributors

Department:
Department of Oncology, University of Oxford
Role:
Supervisor
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Funding agency for:
Mustak Ibn Ayub
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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