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A cellular model for the investigation of depot-specific human adipocyte biology

Abstract:

Upper-body adiposity is associated with increased metabolic disease risk, whilst lower-body adiposity is paradoxically protective. Efforts to understand the underlying mechanisms require appropriate and reproducible in vitro culture models. We have therefore generated immortalised (im) human preadipocyte (PAD) cell lines derived from paired subcutaneous abdominal and gluteal adipose tissue. These cell lines, denoted imAPAD and imGPAD display enhanced proliferation and robust adipogenic capaci...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1080/21623945.2016.1277052

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Taylor and Francis Publisher's website
Journal:
Adipocyte Journal website
Volume:
6
Issue:
1
Pages:
40/55
Publication date:
2017-01-01
Acceptance date:
2016-12-20
DOI:
EISSN:
2162-397X
ISSN:
2162-3945
Keywords:
Pubs id:
pubs:668035
UUID:
uuid:95b92e61-e358-4dfa-bf4f-dd964a95d47e
Local pid:
pubs:668035
Deposit date:
2017-01-04

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