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The evolution of a genetic locus encoding small serine proteinase inhibitors.

Abstract:

We previously identified a locus on human chromosome 20 that encompasses 14 genes of postulated WFDC-type proteinase inhibitors with a potential role in innate immunity. In an extended study, homologous loci are here described on mouse chromosome 2, rat chromosome 3, and dog chromosome 24. As in humans, the murine and canine loci are divided into two sub-loci separated by 0.2Mb. The majority of genes are conserved in all species, but there are also species-specific gains and losses of genes, ...

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Publisher copy:
10.1016/j.bbrc.2005.05.125

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Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Lundwall, A More by this author
Journal:
Biochemical and biophysical research communications
Volume:
333
Issue:
2
Pages:
383-389
Publication date:
2005-07-05
DOI:
EISSN:
1090-2104
ISSN:
0006-291X
URN:
uuid:95b6e573-0e94-4f36-bd6e-cbc6369b647d
Source identifiers:
365972
Local pid:
pubs:365972

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