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Disease evolution in multiple sclerosis

Abstract:

Multiple sclerosis is a long-term disease that evolves over a period of 30 to 40 years with progressive accumulation of unremitting disability. When developing treatments for multiple sclerosis, it is important to be able to measure accurately the impact of treatments on disability progression. An analysis of 31 previous clinical trials revealed that small changes in EDSS scores measured across two or three years may be insufficiently sensitive to detect sustained changes in disability reliab...

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Publication status:
Published

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Publisher copy:
10.1007/s00415-006-6002-y

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Volume:
253
Issue:
SUPPL. 6
Pages:
3-8
Publication date:
2006-11-05
DOI:
EISSN:
1432-1459
ISSN:
0340-5354
URN:
uuid:95aaab8b-5e98-4c01-b5fd-f71ec4aaeb11
Source identifiers:
40167
Local pid:
pubs:40167

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