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Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.

Abstract:

The concept of susceptibility genes common to different autoimmune diseases is now firmly established with previous studies demonstrating overlap of loci conferring susceptibility to type 1 diabetes (T1D) with both Coeliac disease and multiple sclerosis. Rheumatoid arthritis (RA) is an archetypal autoimmune disease and we, therefore, targeted putative T1D susceptibility loci for genotyping in UK RA cases and unrelated controls. A novel RA susceptibility locus at AFF3 was identified with convi...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddp177

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Journal:
Human molecular genetics
Volume:
18
Issue:
13
Pages:
2518-2522
Publication date:
2009-07-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:9592fc96-c155-4401-b641-3f1b10fa49b6
Source identifiers:
108361
Local pid:
pubs:108361

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