Journal article icon

Journal article

Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology

Abstract:

Transcription of DNA is essential for cell maintenance and survival; inappropriate localization of proteins that are involved in transcription would be catastrophic. In Alzheimer's disease brains, and in vitro studies, we have found qualitative and quantitative deficits in transport into the nucleus of DNA methyltransferase 1 (DNMT1) and RNA polymerase II (RNA pol II), accompanied by their abnormal sequestration in the cytoplasm. RAN (RAs-related Nuclear protein) knockdown, by siRNA and oligo...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pone.0053349

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Expand authors...
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
8
Issue:
1
Pages:
e53349
Publication date:
2013-01-08
Acceptance date:
2012-11-27
DOI:
EISSN:
1932-6203
URN:
uuid:95844881-3fe4-4956-b5af-18a6d468eafe
Source identifiers:
456143
Local pid:
pubs:456143

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP