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Structural and functional characterization of Salmonella enterica serovar Typhimurium YcbL: an unusual Type II glyoxalase.

Abstract:

YcbL has been annotated as either a metallo-β-lactamase or glyoxalase II (GLX2), both members of the zinc metallohydrolase superfamily, that contains many enzymes with a diverse range of activities. Here, we report crystallographic and biochemical data for Salmonella enterica serovar Typhimurium YcbL that establishes it as GLX2, which differs in certain structural and functional properties compared with previously known examples. These features include the insertion of an α-helix after residu...

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Publication status:
Published

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Publisher copy:
10.1002/pro.475

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Journal:
Protein science : a publication of the Protein Society
Volume:
19
Issue:
10
Pages:
1897-1905
Publication date:
2010-10-05
DOI:
EISSN:
1469-896X
ISSN:
0961-8368
URN:
uuid:9583940a-994b-4f32-9b3b-64b29a27adf1
Source identifiers:
72656
Local pid:
pubs:72656

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