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Salicylates used in inflammatory bowel disease and colchicine impair interferon-gamma induced HLA-DR expression.

Abstract:

Colonic epithelial cells express HLA-DR in inflammatory bowel disease. The effect of drugs used in the treatment of inflammatory bowel disease and colchicine on interferon-gamma (IFN-gamma) induced DR expression has been investigated. HT-29 cells were cultured in 25 cm2 flasks. At 48 hours interferon-gamma (0, 50, or 100 U/ml) +/- drug were added. At 120 hours the cells were stained for HLA-DR and analysed by flow cytometry. 10(-2) M 5ASA reduced DR expression induced by 50 U/ml interferon-ga...

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Publication status:
Published

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Publisher copy:
10.1136/gut.33.1.59

Authors


Dalton, HR More by this author
Jewell, DP More by this author
Journal:
Gut
Volume:
33
Issue:
1
Pages:
59-64
Publication date:
1992-01-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:957cd64b-42aa-4ecb-b6f0-67c0a9f4de3c
Source identifiers:
135448
Local pid:
pubs:135448

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