Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.

Journal article

BACKGROUND AND OBJECTIVES: Chronic widespread pain (CWP) is a common disorder affecting ∼10% of the general population and has an estimated heritability of 48-52%. In the first large-scale genome-wide association study (GWAS) meta-analysis, we aimed to identify common genetic variants associated with CWP. METHODS: We conducted a GWAS meta-analysis in 1308 female CWP cases and 5791 controls of European descent, and replicated the effects of the genetic variants with suggestive evidence for ass...

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Authors: Peters, M; Broer, L; Willemen, H; Eiriksdottir, G; Hocking, L

• Publication status: Published
• Journal: Annals of the rheumatic diseases
• Volume: 72
• Issue: 3
• Pages: 427-436
• Publication date: 2013-03-01
• DOI: 10.1136/annrheumdis-2012-201742
• EISSN: 1468-2060
• ISSN: 0003-4967
• Language: English
• Keywords: Chromosomes, Human, Pair 5; Chronic Pain; Mice; Animals; Genome-Wide Association Study; Female; Genetic Predisposition to Disease; Disease Models, Animal; Polymorphism, Single Nucleotide; Humans; Genotype