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Controlling the kinetics of self-reproducing micelles by catalyst compartmentalization in a biphasic system

Abstract:

Compartmentalization of reactions is ubiquitous in biochemistry. Self-reproducing lipids are widely studied as chemical models of compartmentalized biological systems. Here, we explore the effect of catalyst location on copper-catalyzed azide-alkyne cycloadditions which drive the self-reproduction of micelles from phase-separated components. Tuning the hydrophilicity of the copper-ligand complex, so that hydro-phobic or -philic catalysts are used in combination with hydro-philic and -phobic c...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.joc.8b03149

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Oxford college:
Worcester College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Keble College
Role:
Author
Publisher:
American Chemical Society
Journal:
Journal of Organic Chemistry More from this journal
Volume:
84
Issue:
5
Pages:
2741–2755
Publication date:
2019-01-30
Acceptance date:
2019-01-30
DOI:
EISSN:
1520-6904
ISSN:
0022-3263
Language:
English
Pubs id:
pubs:967181
UUID:
uuid:95560274-a6bc-429f-91f7-4c56164059e4
Local pid:
pubs:967181
Source identifiers:
967181
Deposit date:
2019-01-31

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