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The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.

Abstract:

Focal cortical dysplasia (FCD) is the most common malformation of cortical development found in epilepsy surgical series. Characterised by cortical mislamination, dysplastic neurons and, in a subgroup of cases, balloon cells, FCD is potently epileptogenic. Despite decades of study, the underlying aetiology of FCD remains uncertain and research has been hampered by the lack of a good animal model in which to simulate the condition. In this article we review some of the potential molecular mech...

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Publisher copy:
10.1159/000109855

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Nikolić, M More by this author
Sisodiya, SM More by this author
Journal:
Developmental neuroscience
Volume:
30
Issue:
1-3
Pages:
96-104
Publication date:
2008
DOI:
EISSN:
1421-9859
ISSN:
0378-5866
URN:
uuid:953c79ab-5013-4414-ade8-09589c853b31
Source identifiers:
461704
Local pid:
pubs:461704

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