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Journal article

DNA and lipid bilayers: self-assembly and insertion.

Abstract:

DNA-lipid complexes are of biomedical importance as delivery vectors for gene therapy. To gain insight into the interactions of DNA with zwitterionic and cationic (dimyristoyltrimethylammonium propane (DMTAP)) lipids, we have used coarse-grained molecular dynamics simulations to study the self-assembly of DPPC and DPPC/DMTAP lipid bilayers in the presence of a DNA dodecamer. We observed the spontaneous formation of lipid bilayers from initial systems containing randomly placed lipids, water-c...

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Publication status:
Published

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Journal:
Journal of the Royal Society, Interface / the Royal Society
Volume:
5 Suppl 3
Issue:
Suppl_3
Pages:
S241-S250
Publication date:
2008-12-01
DOI:
EISSN:
1742-5662
ISSN:
1742-5689
Source identifiers:
100571
Language:
English
Keywords:
Pubs id:
pubs:100571
UUID:
uuid:953c101a-ba7a-490d-854a-07b18bafd7dc
Local pid:
pubs:100571
Deposit date:
2012-12-19

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