Journal article icon

Journal article

Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine

Abstract:

We here review primary methods used in quantifying and mapping 5-hydroxymethylcytosine (5hmC), including global quantification, restriction enzyme-based detection, and methods involving DNA-enrichment strategies and the genome-wide sequencing of 5hmC. As discovered in the mammalian genome in 2009, 5hmC, oxidized from 5-methylcytosine (5mC) by ten-eleven translocation (TET) dioxygenases, is increasingly being recognized as a biomarker in biological processes from development to pathogenesis, a...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

Actions


Access Document


Files:
Publisher copy:
10.1002/bies.201700010

Authors


More by this author
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Role:
Author
Expand authors...
Publisher:
Wiley-VCH Verlag Publisher's website
Journal:
BioEssays Journal website
Volume:
39
Issue:
5
Pages:
1700010
Publication date:
2017-03-23
Acceptance date:
2017-03-01
DOI:
EISSN:
1521-1878
ISSN:
0265-9247
Pubs id:
pubs:684213
URN:
uri:95397fe3-02dc-4af9-9114-5121a9638cd5
UUID:
uuid:95397fe3-02dc-4af9-9114-5121a9638cd5
Local pid:
pubs:684213

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP