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Journal article

The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.

Abstract:

The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are largely unknown. The transcription factor Eomes/Tbr2 is transiently expressed in cortical SVZ progenitor cells. Here we demonstrate that conditional inactivation of Tbr2 during early brain development causes microcephaly and severe behavioral deficits. In Tbr2 mutants the number of SVZ progenitor cells is reduc...

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Publication status:
Published

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Publisher copy:
10.1101/gad.475408

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Journal:
Genes and development
Volume:
22
Issue:
18
Pages:
2479-2484
Publication date:
2008-09-05
DOI:
EISSN:
1549-5477
ISSN:
0890-9369
URN:
uuid:9526e4b1-d6fe-4f9c-bbc4-70b1f778d2ee
Source identifiers:
22141
Local pid:
pubs:22141

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