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An investigation of the factors effecting high-risk individuals’ decision-making about prophylactic total gastrectomy and surveillance for hereditary diffuse gastric cancer (HDGC)

Abstract:

Hereditary Diffuse Gastric Cancer (HDGC) has an early onset and poor prognosis, therefore, individuals who carry a pathogenic (CDH1) mutation in the E-cadherin gene (CDH1) are offered endoscopic surveillance and advised to undergo prophylactic total gastrectomy (PTG) in their early to mid-twenties. Patients not ready or fit to undergo gastrectomy, or in whom the genetic testing result is unknown or ambiguous, are offered surveillance. Little is known about the factors that influence decision...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1007/s10689-016-9910-8

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health
Richardson, S More by this author
Hardwick, RH More by this author
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Sir Halley Stewart Trust More from this funder
Publisher:
Springer Verlag Publisher's website
Journal:
Familial Cancer Journal website
Volume:
15
Issue:
4
Pages:
665-676
Publication date:
2016-06-02
DOI:
EISSN:
1573-7292
ISSN:
1389-9600
URN:
uuid:952027b1-f061-4271-b998-8e86937a82ca
Source identifiers:
622991
Local pid:
pubs:622991

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