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Signal-regulatory protein α from the NOD mouse binds human CD47 with an exceptionally high affinity-- implications for engraftment of human cells.

Abstract:

One common way to study human leucocytes and cancer cells in an experimental in vivo situation is to use mice that have been genetically engineered to lack an immune system and prevent human cell rejection. These mice lack CD132 and either RAG2 or the catalytic subunit of the DNA-dependent protein kinase, to make the mice deficient in lymphocytes and natural killer cells. The NOD mouse strain provides a better background for engraftment than other strains due to stronger engagement of the sig...

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Publication status:
Published

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Publisher copy:
10.1111/imm.12290

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Journal:
Immunology
Volume:
143
Issue:
1
Pages:
61-67
Publication date:
2014-09-05
DOI:
EISSN:
1365-2567
ISSN:
0019-2805
URN:
uuid:951f4755-d43e-4ece-874e-31c7c7054617
Source identifiers:
463173
Local pid:
pubs:463173

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