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Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.

Abstract:

1. We have studied the electrophysiological properties of cloned ATP-sensitive K+ channels (KATP channels) heterologously expressed in Xenopus oocytes. This channel comprises a sulphonylurea receptor subunit (SUR) and an inwardly rectifying K+ channel subunit (Kir). 2. Oocytes injected with SUR1 and either Kir6.2 or Kir6.1 exhibited large inwardly rectifying K+ currents when cytosolic ATP levels were lowered by the metabolic inhibitors azide or FCCP. No currents were observed in response to a...

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Publication status:
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Authors


Gribble, FM More by this author
Ashfield, R More by this author
Ammälä, C More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
The Journal of physiology
Volume:
498 ( Pt 1)
Issue:
1
Pages:
87-98
Publication date:
1997-01-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:951a556c-63cf-4c73-8294-0a3d2198c364
Source identifiers:
114053
Local pid:
pubs:114053

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