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Electrophysiological evidence for convergence of inputs from the medial prefrontal cortex and lateral habenula on single neurons in the dorsal raphe nucleus.

Abstract:

Neuronal projections to the dorsal raphe nucleus (DRN) from the medial prefrontal cortex (mPFC) and lateral habenula nucleus (LHb) provide the two key routes by which information processed by mood regulatory, cortico-limbic-striatal circuits input into the 5-HT system. These two projections may converge as it appears that both activate local GABAergic neurons to inhibit 5-HT neurons in the DRN. Here we have tested this hypothesis by measuring the effect of stimulation of the mPFC and LHb on t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
The European journal of neuroscience
Volume:
17
Issue:
2
Pages:
280-286
Publication date:
2003-01-05
DOI:
EISSN:
1460-9568
ISSN:
0953-816X
URN:
uuid:9517a95d-e17f-44cb-ba6b-e75e34321745
Source identifiers:
185320
Local pid:
pubs:185320

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