Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

Journal article

GATA-1 and PU.1 are transcription factors that control erythroid and myeloid development, respectively. The two proteins have been shown to function in an antagonistic fashion, with GATA-1 repressing PU.1 activity during erythropoiesis and PU.1 repressing GATA-1 function during myelopoiesis. It has also become clear that this functional antagonism involves direct interactions between the two proteins. However, the molecular basis for these interactions is not known, and a number of inconsiste...

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Authors: Liew, C; Rand, K; Simpson, R; Yung, W; Mansfield, R

• Journal: Journal of biological chemistry
• Volume: 281
• Issue: 38
• Pages: 28296-28306
• Publication date: 2006-09-01
• DOI: 10.1074/jbc.m602830200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Proto-Oncogene Proteins; Animals; Binding Sites; Trans-Activators; Phosphorylation; Mice; Zinc Fingers; GATA1 Transcription Factor; Humans; Amino Acid Motifs; Hematopoiesis; DNA; Acetylation; Molecular Sequence Data; Amino Acid Sequence