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Journal article

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells

Abstract:

The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease in humans. Here, we demonstrate in the mouse that the Prdm1 (Blimp1) gene was partially activated at the chromatin and transcription level in early B cell development, although mature Prdm1 mRNA did not accumulate due to posttranscriptional regulation. By analyzing a mouse model that facilitated ectopic Blimp1 protein expression throughout B lymp...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.15252/embj.2018100010

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Oxford Ludwig Institute
Role:
Author
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Publisher:
EMBO Press Publisher's website
Journal:
EMBO Journal Journal website
Volume:
38
Issue:
2
Publication date:
2018-11-29
Acceptance date:
2018-11-02
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:954675
URN:
uri:94fc0c51-bf36-417f-9181-8804543e8569
UUID:
uuid:94fc0c51-bf36-417f-9181-8804543e8569
Local pid:
pubs:954675

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