- Abstract:
-
BACKGROUND: In patients with chronic lymphoid leukemia (CLL) or small lymphocytic lymphoma (SLL), a short duration of response to therapy or adverse cytogenetic abnormalities are associated with a poor outcome. We evaluated the efficacy of ibrutinib, a covalent inhibitor of Bruton's tyrosine kinase, in patients at risk for a poor outcome. METHODS: In this multicenter, open-label, phase 3 study, we randomly assigned 391 patients with relapsed or refractory CLL or SLL to receive daily ibrutinib...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1056/nejmoa1400376
-
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- Publisher:
- Massachussetts Medical Society
- Journal:
- The New England journal of medicine
- Volume:
- 371
- Issue:
- 3
- Pages:
- 213-223
- Publication date:
- 2014-07-05
- DOI:
- EISSN:
-
1533-4406
- ISSN:
-
0028-4793
- URN:
-
uuid:94ed6162-805c-4b48-8ada-f98fabde922f
- Source identifiers:
-
477988
- Local pid:
- pubs:477988
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.
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