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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Abstract:

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Ass...

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Publication status:
Published

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Publisher copy:
10.1038/ng.2500

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Journal:
Nature genetics
Volume:
45
Issue:
2
Pages:
145-154
Publication date:
2013-02-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:94e48a8c-b5ae-4a7e-95fc-b5509e3db292
Source identifiers:
369958
Local pid:
pubs:369958

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