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Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.

Abstract:

Objective

To investigate whether cartilage injury activates protein tyrosine kinases distinct from fibroblast growth factor (FGF)–related signaling, and whether they contribute to injury-induced gene responses.

Methods

Phosphokinases and protein tyrosine phosphorylation were assayed by Western blotting of cartilage lysates. Immunoprecipitation and Western blotting with 4G10 antibody and immunoprecipitation kinase assay were carried out. Tyrosine-phosphorylated prot...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/art.37765

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
Didangelos, A More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Arthritis Research UK More from this funder
Wellcome Trust More from this funder
GlaxoSmithKline More from this funder
Publisher:
Wiley Publisher's website
Journal:
Arthritis and Rheumatism Journal website
Volume:
65
Issue:
2
Pages:
397-407
Publication date:
2012-11-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:94db42f5-95b9-47b2-bbe0-bab71dd8885c
Source identifiers:
358490
Local pid:
pubs:358490

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