Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.
To investigate whether cartilage injury activates protein tyrosine kinases distinct from fibroblast growth factor (FGF)–related signaling, and whether they contribute to injury-induced gene responses.
Phosphokinases and protein tyrosine phosphorylation were assayed by Western blotting of cartilage lysates. Immunoprecipitation and Western blotting with 4G10 antibody and immunoprecipitation kinase assay were carried out. Tyrosine-phosphorylated prot...Expand abstract
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