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Physico-chemical characterization of functional electrospun scaffolds for bone and cartilage tissue engineering.

Abstract:

Mimicking the zonal organization of the bone-cartilage interface will aid the production of functional osteochondral grafts for regeneration of skeletal joint defects. This study investigates the potential of the electrospinning technique to build a three-dimensional construct recapitulating the zonal matrix of this interface. Poly(lactic-co-glycolic acid) (PLGA) and PLGA-collagen solutions containing different concentrations of hydroxyapatite nanoparticles (nHAp) were electrospun on a thin l...

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Publication status:
Published

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Publisher copy:
10.1243/09544119jeim824

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Journal:
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Volume:
224
Issue:
12
Pages:
1401-1414
Publication date:
2010-12-05
DOI:
EISSN:
2041-3033
ISSN:
0954-4119
URN:
uuid:94cfb516-bd8d-4881-99e6-328f0cf6ec80
Source identifiers:
107135
Local pid:
pubs:107135

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