Physico-chemical characterization of functional electrospun scaffolds for bone and cartilage tissue engineering.

Journal article

Mimicking the zonal organization of the bone-cartilage interface will aid the production of functional osteochondral grafts for regeneration of skeletal joint defects. This study investigates the potential of the electrospinning technique to build a three-dimensional construct recapitulating the zonal matrix of this interface. Poly(lactic-co-glycolic acid) (PLGA) and PLGA-collagen solutions containing different concentrations of hydroxyapatite nanoparticles (nHAp) were electrospun on a thin l...

Expand abstract

Authors: Mouthuy, P; Ye, H; Triffitt, J; Oommen, G; Cui, Z

• Publication status: Published
• Journal: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• Volume: 224
• Issue: 12
• Pages: 1401-1414
• Publication date: 2010-12-01
• DOI: 10.1243/09544119jeim824
• EISSN: 2041-3033
• ISSN: 0954-4119
• Language: English
• Keywords: Equipment Failure Analysis; Tissue Scaffolds; Compressive Strength; Tensile Strength; Humans; Porosity; Bone Substitutes; Equipment Design; Elastic Modulus; Manufactured Materials; Animals; Hardness; Bone Development; Cartilage; Rotation; Tissue Engineering