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Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart.

Abstract:

PURPOSE: Butyrate, a short chain fatty acid, was studied as a novel hyperpolarized substrate for use in dynamic nuclear polarization enhanced magnetic resonance spectroscopy experiments, to define the pathways of short chain fatty acid and ketone body metabolism in real time. METHODS: Butyrate was polarized via the dynamic nuclear polarization process and subsequently dissolved to generate an injectable metabolic substrate. Metabolism was initially assessed in the isolated perfused rat heart,...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/mrm.24849

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Magnetic resonance in medicine Journal website
Volume:
71
Issue:
5
Pages:
1663-1669
Publication date:
2014-05-05
DOI:
EISSN:
1522-2594
ISSN:
0740-3194
URN:
uuid:94cb3034-92c9-4c3c-933b-f1f58321fe1f
Source identifiers:
407773
Local pid:
pubs:407773

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