Journal article icon

Journal article

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Abstract:

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in gene...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/ncomms15805

Authors


Tragante, V More by this author
Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Article number:
15805
Publication date:
2017-06-14
Acceptance date:
2017-05-08
DOI:
ISSN:
2041-1723
Pubs id:
pubs:700897
UUID:
uuid:94c5b2fa-fd25-4b2e-aa40-6f3146d39aae
Source identifiers:
700897
Local pid:
pubs:700897
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP