- Abstract:
-
The purpose of this study was to evaluate the contribution of DT-diaphorase inhibition to in vivo neurodegenerative effects of dopamine (DA) oxidation to the corresponding o-quinones. The neurotoxicity to nigrostriatal DA neurons was induced by injection of manganese pyrophosphate (Mn(3+)) complex as a prooxidizing agent alone or together with the DT-diaphorase inhibitor dicumarol into the right rat substantia nigra. The behavioral effects were compared with those induced after selective lesi...
Expand abstract - Publisher copy:
- 10.1016/j.pbb.2003.10.016
-
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- Journal:
- Pharmacology, biochemistry, and behavior
- Volume:
- 77
- Issue:
- 2
- Pages:
- 245-251
- Publication date:
- 2004-02-05
- DOI:
- EISSN:
-
1873-5177
- ISSN:
-
0091-3057
- URN:
-
uuid:94b8abea-81b3-4f39-a95a-c1dd1a11a31f
- Source identifiers:
-
425169
- Local pid:
- pubs:425169
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor.
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