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Mechanical forces impair antigen discrimination by reducing differences in T cell receptor off-rates

Abstract:

T cells use their T cell receptors (TCRs) to discriminate between lower‐affinity self and higher‐affinity foreign peptide major‐histocompatibility‐complexes (pMHCs) based on the TCR/pMHC off‐rate. It is now appreciated that T cells generate mechanical forces during this process but how force impacts the TCR/pMHC off‐rate remains debated. Here, we measured the effect of mechanical force on the off‐rate of multiple TCR/pMHC interactions. Unexpectedly, we found that lower‐affinity pMHCs wit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embj.2022111841

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
ORCID:
0000-0001-5847-5226
More from this funder
Name:
Wellcome Trust
Grant:
207537/Z/17/Z
Publisher:
EMBO Press
Journal:
EMBO Journal More from this journal
Volume:
42
Article number:
e111841
Publication date:
2022-12-09
Acceptance date:
2022-11-11
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
1305111
Local pid:
pubs:1305111
Deposit date:
2022-11-21

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